Bone marrow transplantation versus immunosuppressive therapy in patients with acquired severe aplastic anemia
نویسندگان
چکیده
منابع مشابه
ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...
متن کاملAcceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia.
We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of th...
متن کاملFirst-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy.
The current treatment approach for severe aplastic anemia in children is based on studies performed in the 1980s, and updated evidence is required. We retrospectively compared the outcomes of children with acquired severe aplastic anemia who received immunosuppressive therapy within prospective trials conducted by the Japanese Childhood Aplastic Anemia Study Group or who underwent bone marrow t...
متن کاملallogenic bone marrow transplantation in aplastic anemia
eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (bmt) from hla-matched siblings during the period of 1990 to 1996. the conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. antilymphocyte globulin (alg) and cyclosporine were used for rejection and acute gvhd prophylaxis, respective...
متن کاملTRANSPLANTATION Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia
1Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; 2Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan; 4Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 5Kanagawa Children’s Hospital...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2016
ISSN: 0925-5710,1865-3774
DOI: 10.1007/s12185-016-2037-8